Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)



Prothrombin Time (PT) - Often Elevated in:

 • Vitamin K deficiency or antagonism (warfarin)

 • Factor VII deficiency or inhibitor

 • Liver disease



Partial Thromboplastin Time (PTT) - Often elevated in:

 • Heparin use

 • Heparinized line

 • Factor XI, IX, VIII deficiency or inhibitor



Both elevated in:

 • DIC

 • Underfilled test tubes 

 • Factor X, V, II, fibrinogen deficiency or inhibitor



Dr. Matt Tsai @thematttsai



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